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KMID : 0377219840090010131
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Medical Journal of Chosun Univercity
1984 Volume.9 No. 1 p.131 ~ p.136
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Changes of Serum Immunoglobuiins IgG,IgA,and IgM in patients with Molar Pregnancy
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Abstract
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Pregnancy has been described as a successful allograft of foreign tissue, and the role of immune reactions in human reproduction is recerving increasing attention. But little is still is known about humoral immunity in pregnancy.
We have studied the relationship between immunoglobulins and molar pregnancy. Molar pregnancy may be an allograft of foreign tissue, and if so, host immune responses should be expected to occur during the course of the disease.
In the present report, we have summarized the serial immunoglobulins and human chorionic gonadotropin (hCG) level. Serial blood samples were obtained immediately before (sample 1) and after (sample 4, at Ist, 4th, 7th, 14th) evacuation of njolar pregnancy.
The hCG is a specific quantitative tumor marker of gestational trophoblastic neoplasia. The hCG was measured by radioimmunoassay.
The concentrations of immunoglobulin (Ig) IgG, IgA and IgM were determined simultaneously. The concentrations of IgG, IgA and IgM decreased significantly in molar pregnancy. After molar evacuation immunoglobulins gradually increased and hCG gradully decreased. But further research must be carried out to determine if the increase in immunoglobulins is caused by the decrease in hCG.
We found that molar pregnacy influenced the immune reaction and that serial measurment of scrum immunoglobulins was useful in evaluating the immunoglobulins was useful in evaluating the immunologic state. This report describes serial measurement of the serum IgG, IgA and IgNT before and after evacuation of molar pregnancy and emphasizes the importance of serial rneasurements for observing changes in immunoglobulins.
Immunoglobulin in molar pregnancy seems to result from both immunesuppressiori apd/or he modilution.
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